Enzyme | Substrate | Single-Substrate IC50 | Cocktail IC50 |
---|---|---|---|
µg/ml | µg/ml | ||
CYP1A2 | Phenacetin | >100 | 83.04 ± 16.96 |
CYP2A6 | Coumarin | >100 | >100 |
CYP2B6 | Bupropion | 15.59 ± 1.79 | 19.58 ± 1.80 |
CYP2C8 | Amodiaquine | 14.36 ± 2.62 | 17.06 ± 1.54 |
CYP2C9 | Tolbutamide | 8.80 ± 1.20 | 12.36 ± 1.14 |
CYP2C19 | (S)-mephenytoin | 12.80 ± 2.34 | 19.68 ± 2.70 |
CYP2D6 | Dextromethorphan | 73.38 ± 11.72 | >100 |
CYP3A4/5 | Midazolam | >100 | >100 |
Testosterone | 35.00 ± 4.81 | 55.64 ± 18.49 | |
CYP2E1 | Chlorzoxazone | >100 | >100 |