TABLE 1

Pharmacokinetic parameters in plasma, skin, and eyes after oral administration of fenofibrate in rats

Samplest1/2CmaxTmaxAUC0–∞MRT
(h)(µg/ml or µg/g tissue)(h)(h▪µg/ml or h▪µg/g tissue)(h)
FF
 PlasmaN.A.N.A.N.A.N.A.N.A.
 SkinN.A.N.A.N.A.N.A.N.A.
 EyeN.A.N.A.N.A.N.A.N.A.
FA
 Plasma6.4 ± 0.406.3 ± 1.19.7 ± 1.197 ± 1413 ± 0.70
 Skin11 ± 1.50.34 ± 0.01713 ± 3.98.5 ± 1.320 ± 2.1
 Eye22 ± 6.90.10 ± 0.00556.0 ± 1.42.6 ± 0.3334 ± 10
RFA
 Plasma12 ± 1.01.6 ± 0.1012 ± 0.033 ± 3.221 ± 1.5
 Skin17 ± 3.30.080 ± 0.006716 ± 4.72.0 ± 0.6030 ± 4.2
 EyeN.A.N.A.N.A.N.A.N.A.

  • AUC0-∞, area under the concentration vs. time curve from t=0 to t=∞ after administration; Cmax, maximum concentration; t1/2, terminal half-life; Tmax, time to maximum concentration; and MRT, mean residence time. Each value represents the mean±SEM for 4–7 rats. N.A., not available due to concentrations below the limit of detection.