Analyte | Cmax (µM) | tmax (h) | AUC0–24h (µM h–1) | AUCtotal (µM h–1) | t1/2 (h) | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
R | S | R | S | R | S | R | S | R | S | |||
MDMA | *** | *** | *** | *** | *** | |||||||
Mean (SD) | 0.72 (0.20) | 0.59 (0.17) | 2.9 (0.7) | 2.1 (0.7) | 9.3 (2.7) | 5.3 (1.7) | 11.2 (4.0) | 5.5 (1.7) | 8.6 (2.6) | 4.6 (0.7) | ||
Median (Range) | 0.70 (0.36–1.2) | 0.56 (0.29–0.95) | 2.7 (1.8–4.6) | 1.9 (1.3–3.6) | 9.6 (4.2–15.2) | 5.5 (2.4–9.0) | 10.8 (4.7–19.0) | 5.9 (2.5–9.4) | 7.7 (5.7–14.4) | 4.4 (3.5–6.1) | ||
MDA | *** | *** | *** | n.d. | n.d. | |||||||
Mean (SD) | 0.014 (0.006) | 0.041 (0.011) | 13.6 (8.3) | 4.5 (0.7) | 0.25 (0.09) | 0.62 (0.17) | n.d. | 0.78 (0.27) | n.d. | 9.5 (2.5) | ||
Median (Range) | 0.014 (0.006–0.032) | 0.038 (0.018–0.061) | 8.0 (6.0–24.0) | 4.4 (3.7–6.1) | 0.25 (0.13–0.5) | 0.61 (0.29–1.1) | n.d. | 0.76 (0.36–1.5) | n.d. | 8.6 (5.0–14.0) | ||
DHMA 3S | *** | n.s. | *** | ** | *** | |||||||
Mean (SD) | 0.13 (0.083) | 0.53 (0.26) | 2.5 (1.7) | 1.6 (0.4) | 2.1 (1.1) | 5.6 (2.8) | 4.3 (2.6) | 6.3 (3.2) | 21.8 (7.7) | 7.2 (1.4) | ||
Median (Range) | 0.11 (0.029–0.31) | 0.49 (0.15–1.1) | 2.1 (0.9–6.4) | 1.7 (1.0–2.5) | 1.9 (0.49–4.5) | 5.2 (1.9–11.2) | 3.5 (0.94–10.1) | 5.6 (2.1–12.7) | 21.2 (9.1–40.6) | 6.9 (5.7–11.6) | ||
DHMA 4S | ** | n.s. | ** | ** | * | |||||||
Mean (SD) | 0.071 (0.047) | 0.050 (0.024) | 2.2 (1.0) | 1.7 (0.5) | 1.1 (0.72) | 0.59 (0.26) | 2.2 (1.6) | 0.76 (0.36) | 21.2 (11.4) | 10.1 (5.3) | ||
Median (Range) | 0.052 (0.029–0.17) | 0.037 (0.017–0.095) | 1.9 (1.2–4.8) | 1.8 (0.9–2.7) | 0.80 (0.38–2.9) | 0.63 (0.23–1.0) | 1.7 (0.46–6.4) | 0.75 (0.30–1.5) | 20.6 (7.6–46.7) | 8.3 (6.3–26.6) | ||
HMMA S | n.s. | n.s. | *** | *** | *** | |||||||
Mean (SD) | 0.31 (0.15) | 0.36 (0.16) | 2.0 (1.2) | 1.8 (0.6) | 4.8 (2.0) | 3.7 (1.5) | 8.3 (3.6) | 4.0 (1.6) | 18.2 (6.0) | 6.6 (0.7) | ||
Median (Range) | 0.31 (0.074–0.62) | 0.34 (0.12–0.70) | 1.6 (1.2–5.8) | 1.8 (0.9–2.7) | 5.2 (1.2–8.5) | 3.6 (1.3–6.4) | 8.7 (2.3–14.1) | 4.1 (1.5–6.8) | 16.5 (12.1–36) | 6.9 (5.2–7.6) | ||
Median (Range) | 0.10 (0.016–0.70) | 0.29 (0.054–1.4) | 3.4 (1.7–9.1) | 2.6 (1.5–4.9) | 1.7 (0.29–10.6) | 3.9 (0.75–14.7) | 3.9 (0.51–16.6) | 4.1 (0.84–15.5) | 15.8 (6.9–61.1) | 5.8 (4.7–9.4) | ||
HMMA G | *** | n.s. | *** | n.s. | *** | |||||||
Mean (SD) | 0.18 (0.18) | 0.41 (0.38) | 3.9 (1.9) | 3.1 (1.0) | 2.8 (2.7) | 4.4 (3.7) | 4.8 (4.1) | 4.7 (3.8 | 21.6 (14.7) | 6.3 (1.2) | ||
Median (Range) | 0.10 (0.016–0.70) | 0.29 (0.054–1.4) | 3.4 (1.7–9.1) | 2.6 (1.5–4.9) | 1.7 (0.29–10.6) | 3.9 (0.75–14.7) | 3.9 (0.51–16.6) | 4.1 (0.84–15.5) | 15.8 (6.9–61.1) | 5.8 (4.7–9.4) |
n.s., not significant; n.d., not determined; *p < 0.05, **p < 0.01, ***p < 0.0.