Derived kinetic parameters for OLZ oxidative metabolism by rP450 enzymes in the presence of BSA [2% (w/v)]
Data are mean ± S.D. from quadruplicate experiments.
| Enzyme/Pathway | Km or S50 | Vmax |
|---|---|---|
| µM | pmol/min per nmol P450 | |
| N-demethylation | ||
| CYP1A2 | 61 ± 20 | 1340 ± 90 |
| CYP2C8 | 30 ± 7 | 1370 ± 210 |
| 7-hydroxylation | ||
| CYP1A2a | 592 ± 85 | 1921 ± 21 |
↵a Kinetic constants from fitting with the Hill model, (n = 0.7).