Effect of ABT on stomach content and intestinal transit in rats dosed with a charcoal meal
The stomach content (g) and the intestinal transit (percentage of the small intestine traveled by the charcoal) were measured 30 minutes after the administration of 2 ml of activated charcoal in control or 50 mg/kg ABT-treated rats. Data are the mean and standard deviation of four rats.
| Stomach Content | Intestinal Transit | |
|---|---|---|
| g | % | |
| Control group | 0.464 ± 0.063 | 67.7 ± 2.3 |
| ABT i.v. 1 hour before charcoal | 3.21*** ± 0.49 | 73.5 ± 11.0 |
| ABT p.o. 16 hours before charcoal | 0.658 ± 0.510 | 69.1 ± 3.6 |
| ABT p.o. 1 hour before charcoal | 3.33*** ± 0.86 | 68.8 ± 3.5 |
Statistically significant differences: *P < 0.05, **P < 0.01, and ***P < 0.001 versus control.