Parameter | Control | VSD | ASD |
---|---|---|---|
One-compartment | |||
V (ml/kg) | 84.2 ± 8.3 | 67.3 ± 6.9 | 61.7 ± 7.11 |
K10 (1/min) | 0.10 ± 0.02 | 0.12 ± 0.02 | 0.13 ± 0.02 |
AIC | 86.6 | 87.1 | 88.2 |
Two-compartmenta | |||
Vc (ml/kg) | 57.2 ± 6.23 | 54.7 ± 4.98 | 52.8 ± 5.92 |
K10 (1/min) | 0.12 ± 0.01 | 0.12 ± 0.01 | 0.12 ± 0.01 |
K12 (1/min) | 0.25 ± 0.02 | 0.16 ± 0.01 | 0.15 ± 0.02 |
K21 (1/min) | 0.25 ± 0.03 | 0.17 ± 0.02 | 0.14 ± 0.02 |
AIC | 61.2 | 59.7 | 62.6 |
A modified modelb | |||
Vc (ml/kg) | 50.1 ± 2.18 | 48.9 ± 2.17 | 47.2 ± 2.11 |
K10 (1/min) | 0.09 ± 0.01 | 0.08 ± 0.01 | 0.08 ± 0.01 |
K20 (1/min) | 0.04 ± 0.01 | 0.04 ± 0.02 | 0.04 ± 0.02 |
K12 (1/min) | 0.23 ± 0.01 | 0.17 ± 0.01 | 0.15 ± 0.01 |
K21 (1/min) | 0.24 ± 0.01 | 0.16 ± 0.01 | 0.15 ± 0.01 |
AIC | 49.6 | 48.3 | 50.1 |