Effects of mutations/polymorphisms in shared motif region of OATs and ORs
| OAT or OR | Variant | Substrate/Ligand with Altered Response | Reference |
|---|---|---|---|
| OAT1(SLC22A6) | R50H | Adefovir, cidofovir, tenofovir | (Bleasby et al., 2005) |
| URAT1(SLC22A12) | R90H | Urate | (Ichida et al., 2004; Cheong et al., 2005) |
| URAT1(SLC22A12) | V138M | Urate | (Ichida et al., 2004) |
| Or15 | A195X | Multiple odorants | (Hughes et al., 2014) |
| OR5A1 | N183D | β-Ionone | (Jaeger et al., 2013) |
| OR2A25 | S75N | Geranyl acetate | (Mainland et al., 2014) |
| OR2B11 | I130S+V198M | Spearmint oil | (Mainland et al., 2014) |
X, various amino acids in Hughes et al. (2014).