Inhibition of OAT1- and OAT6-mediated uptake
| Odorant/Inhibitor | OAT1 IC50 | OAT6 IC50 |
|---|---|---|
| μM | μM | |
| 4-Bromobutyric acid | 45.3 | 1346 |
| 6-Bromohexanoic acid | 1012 | 16 |
| Hexyl acetate | 998 | 1149 |
| Amyl hexanoate | 444 | >3000 |
| Methyl octanoate | >3000 | 158 |
| Allyl heptanoate | >3000 | >3000 |
| Probenecid | 4.1 | 28 |
Software: GraphPad Prism, nonlinear regression fit. Tracer: OAT1-mediated uptake, 10 microM 6-CF; OAT6-mediated uptake, 10 microM fluorescein.