Pharmacokinetic parameters estimated from fitting the modified PK model (Fig. 1A) to individual data
The mean value of each parameter for each study group was obtained by averaging the values derived from the individuals. Data presented as means ± S.D.
| Parameter | Control | VSD | ASD |
|---|---|---|---|
| Vc (ml/kg) | 42.2 ± 6.72 | 50.5 ± 11.1 | 41.3 ± 6.56 |
| K10 (1/min) | 0.10 ± 0.05 | 0.08 ± 0.002 | 0.09 ± 0.003 |
| K12 (1/min) | 0.37 ± 0.17 | 0.14 ± 0.04** | 0.16 ± 0.04** |
| K21 (1/min) | 0.23 ± 0.08 | 0.15 ± 0.06* | 0.14 ± 0.06* |
| K20 (1/min) | 0.03 ± 0.01 | 0.04 ± 0.02 | 0.04 ± 0.02 |
| t1/2α (min) | 1.31 ± 0.05 | 2.29 ± 0.08*** | 2.08 ± 0.05*** |
| t1/2β (min) | 19.3 ± 6.78 | 21.2 ± 7.08 | 21.0 ± 7.42 |
| CL (ml/min per kg) | 6.86 ± 1.45 | 6.72 ± 1.34 | 6.51 ± 1.18 |
| Vss (ml/kg) | 142 ± 37.9 | 142 ± 29.9 | 129 ± 29.2 |
| MRT (min) | 23.3 ± 8.76 | 24.6 ± 9.45 | 24.7 ± 8.91 |
| AUC (min × μg/ml) | 23.8 ± 5.18 | 28.6 ± 6.57* | 30.5 ± 6.65** |
AUC, area under the curve; CL, clearance; MRT, mean residence time; t1/2α, distribution half-life; t1/2β, elimination half-time; Vc, volume of the central compartment; Vss, steady-state volume of distribution.
↵* P < 0.05; **P < 0.01; ***P < 0.001 (compared with the control group).