FST-ΔHBS-Fc Variant | Cmax | AUC0–last | CL | Vss | t1/2 |
---|---|---|---|---|---|
μg/ml | μg•h/ml | ml/h/kg | ml/kg | h | |
MV9 16% SA | 7.9 (2.1) | 400 (23) | 2.01 | 570 | 277 |
MV9 27% SA | 12.1 (0.3) | 546 (15) | 1.59 | 346 | 200 |
MV9 33% SA | 13.9 (1.2) | 681 (19) | 1.19 | 326 | 247 |
MV9 60% SA | 20.3 (0.7) | 1304 (24) | 0.64 | 162 | 181 |
MV12 36% SA | 12.5 (0.7) | 567 (13) | 1.49 | 350 | 194 |
MV12 70% SA | 17.7 (2.5) | 979 (69) | 0.75 | 258 | 289 |
AUC0–last, area under the serum concentration curve from 0 to last concentration versus time point; CL, clearance; Vss, volume of distribution at steady state; t1/2, elimination half-life.