Parameters | Control | ABT i.v.a | ABT p.o.b |
---|---|---|---|
Metoprolol | |||
AUC0–T (μg*h/ml) | 0.166 ± 0.215 | 1.08 ± 0.37* | 2.69 ± 0.77***### |
Tmax (hours) | 0.250 | 5.90 ± 4.98* | 0.500# |
Cmax (μg/ml) | 0.255 ± 0.296 | 0.233 ± 0.028 | 1.29 ± 0.37***### |
T1/2 (hours) | 0.524 ± 0.141 | 3.98 ± 3.92 | 0.936 ± 0.199 |
ODM | |||
AUC0–T (μg*h/ml) | 0.279 ± 0.114 | 0.0439 ± 0.0289*** | 0.183 ± 0.034# |
Tmax (hours) | 0.350 ± 0.137 | 6.10 ± 4.75* | 1.30 ± 0.67# |
Cmax (μg/ml) | 0.138 ± 0.075 | 0.0224 ± 0.0058** | 0.0561 ± 0.0153* |
T1/2 (hours) | 1.39 ± 0.366 | N.D. | 2.00 ± 0.589 |
OHM | |||
AUC0–T (μg*h/ml) | 1.05 ± 0.21 | 1.92 ± 0.32* | 2.05 ± 0.77* |
Tmax (hours) | 0.350 ± 0.137 | 6.10 ± 4.75* | 0.500# |
Cmax (μg/ml) | 0.718 ± 0.229 | 0.169 ± 0.048* | 1.29 ± 0.37**### |
T1/2 (hours) | 1.57 ± 0.943 | 27.6 ± 44.4 | 2.22 ± 0.366 |
MA | |||
AUC0–-T (μg*h/ml) | 12.2 ± 1.1 | 11.3 ± 1.3 | 11.3 ± 0.7 |
Tmax (hours) | 1.00 | 6.40 ± 4.34* | 1.80 ± 0.45# |
Cmax (μg/ml) | 4.86 ± 1.00 | 1.02 ± 0.18*** | 3.16 ± 0.44**### |
T1/2 (hours) | 2.78 ± 0.513 | 14.5 ± 24.4 | 2.60 ± 1.39 |
T1/2, half-life.
↵a Rats were treated i.v. with 50 mg/kg of ABT 1 hour before the administration of metoprolol.
↵b Rats were treated p.o. with 50 mg/kg of ABT 16 hours before the administration of metoprolol.
Statistically significant differences: *P < 0.05, **P < 0.01, and ***P < 0.001 for ABT i.v. and p.o. versus control; #P < 0.05, ##P < 0.01, and ###P < 0.001 for ABT i.v. versus ABT p.o.