TABLE 2

Mass spectral characteristics of the in vitro metabolites of PF-06282999

All metabolites were observed in liver microsomes and hepatocytes from preclinical species and humans.

MetaboliteMH+Retention Time (tR)StructureFragment Ions
min
Parent326.036129Embedded Image281.0144, 222.0315, 155.0256
M1296.043321.9Embedded Image251.0214, 235.0265 (-S), 208.0156
M2312.020424.1Embedded Image266.9986, 208.0157
M3a310.058925.7Embedded Image265.0372, 222.0314, 155.0253
  • a The structure of M3 was unambiguously confirmed by comparison of its LC-MS/MS characteristics with an authentic standard.