TABLE 2

Mass spectral characteristics of the in vitro metabolites of PF-06282999

All metabolites were observed in liver microsomes and hepatocytes from preclinical species and humans.

Metabolite	MH+	Retention Time (t_R)	Fragment Ions
		min
Parent	326.0361	29	281.0144, 222.0315, 155.0256
M1	296.0433	21.9	251.0214, 235.0265 (-S), 208.0156
M2	312.0204	24.1	266.9986, 208.0157
M3^a	310.0589	25.7	265.0372, 222.0314, 155.0253

↵^a The structure of M3 was unambiguously confirmed by comparison of its LC-MS/MS characteristics with an authentic standard.