TABLE 4

Hepatobiliary disposition of PF-06282999 in SCHHs

CompoundApparent Intrinsic Uptake ClearancePassive Uptake ClearanceaActive UptakeApparent Intrinsic Biliary ClearanceBiliary Excretion Index
µl/min per mg protein%µl/min per mg protein%
PF-062829992.31.7250.211
Rosuvastatin8.50.9893.549
  • a Uptake was measured in the presence of rifamycin SV (100 µM).