TABLE 9

Summary of urinary excretion of PF-06282999 in healthy fasted male subjects after single p.o. doses administered as solution

Geometric means ± S.D. are presented for A_{e, urine, (0–24 h)} and CL_renal.

Dose	A_{e,urine,(0–24 h)}	A_{e,urine,(0–24 h)}	CL_renal	CL_renal,u^{^a}
mg	mg	% of dose	ml/min
20	13.3 ± 1.7	66.7 ± 8.5	127 ± 18	338
50	36.3 ± 3.2	72.4 ± 6.4	144 ± 14	383
125	86.9 ± 8.3	69.5 ± 6.6	138 ± 26	367
200	151.1 ± 12.6	75.5 ± 6.2	151 ± 21	402

↵^a CL_renal,u was estimated by dividing CL_renal by human plasma unbound fraction of 0.376.