TABLE 2

Concentrations (median and range) of EFV and its metabolites in plasma, CSF, and urine in patients under EFV regimen

PlasmaCSFUrine
Concentrations (n = 71)Metabolites /EFV ratios (n = 71)Concentrations (n = 10)aCSF/ Plasma ratios (n = 7)bUrine/CRT ratios (n = 8)
MedianRangeMedianRangeMedianRangeMedianRangeMedianRange
ng/mlng/ml%%ng/mlng/ml%%microgram/micromole of creatininemicrogram/micromole of creatinine
EFV2100326–46,232NANA169–1431.50.4–4.20.010.002–0.02
8OH-EFV920–108630–6640–112.50–4.60.150.073–1.13
8OH-EFV-gln5827414–17,10725415–16073515–560.450.28–1.5193.610–29.80
8OH-EFV-sulfate7710–12,611360–547100–291.250–13.40.030.007–0.05
7OH-EFV00–43200–300000–00.030.016–0.1
7OH-EFV-gln9490–11,797400–2186.50–130.440–1.52.081.022–9.50
7OH-EFV-sulfate2690–301911.50–960000–00.120.05–0.52

  • CRT, creatinine urine levels micromole/L; NA, Not applicable.

  • ↵a EFV metabolite concentrations were determined in 10 samples.

  • ↵b Only 7 out of 10 CSF samples were available as paired CSF/plasma samples.