TABLE 2

Parameters describing the kinetics of MFM transport by cynomolgus monkey and human OCT2, MATE1, and MATE2K

Transporter	K_t	V_max	Cl_int	V_max Ratio^a	CL_int Ratio^a
Transporter	µM	nmol/min/mg protein	µl/min/mg protein	V_max Ratio^a	CL_int Ratio^a
cOCT2	628 ± 66.2	66.0 ± 5.0	105	0.64	1.50
hOCT2	1465 ± 165	153 ± 13.4	104	0.64	1.50

cMATE1	340 ± 29.4	5.9 ± 0.34	17.4	1.24	0.84
hMATE1	228 ± 15.3	4.5 ± 0.19	19.7	1.24	0.84

cMATE2K	1566 ± 407	15.9 ± 1.8	10.2	1.00	0.52
hMATE2K	819 ± 69.5	7.1 ± 0.24	8.7	1.00	0.52

Data are shown as mean ± S.D. (n = 3). The kinetic parameters were determined as indicated under Materials and Methods.
Intrinsic transport clearance (CL_int) was determined by dividing the V_max value by the K_t value.
↵^a Monkey-to-human V_max and CL_int ratios are normalized to the expression of individual transporter protein.