NON | BPB | Hu1624 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
HepatoPac | Monoculture | HepatoPac | Monoculture | HepatoPac | Monoculture | |||||||
Emax | EC50 | Emax | EC50 | Emax | EC50 | Emax | EC50 | Emax | EC50 | Emax | EC50 | |
μM | μM | μM | μM | μM | μM | |||||||
Rifampin | 10.7 (0.67) | 0.4 (0.09) | 6.7 (0.44) | 0.8 (0.15) | 7.0 (0.28) | 0.3 (0.07) | ND | ND | 7.3 (0.29) | 0.3 (0.07) | 5.3 (0.11) | 0.5 (0.047) |
Phenobarbital | 13.1 (1.25) | 251.4 (0.1) | 7.9 (0.51) | 131.5 (0.1) | 16.9 (4.8) | 221.4 (0.33) | 8.7 (1.3) | 217.2 (0.13) | 14.9 (1.2) | 143.1 (0.1) | 6.5 (0.24) | 91.4 (0.065) |
Phenytoin | 18.3 (9.6) | 66.7 (0.83) | ND | ND | 13.3 (1.03) | 13.3 (0.12) | 6.0 (0.39) | 8.5 (0.162) | 9.7 (0.46) | 5.0 (0.09) | 6.7 (0.21) | 7.5 (0.07) |
ND, curves could not be fit to a sigmoidal Emax model.
mRNA change was measured using real-time PCR with TaqMan probes. Data shown are mean (S.E.) of three determinations.