Predicted Human Pharmacokinetics Parametera | Rat | Dog | Monkey |
---|---|---|---|
CLp (ml/min per kilogram) | 8.6 | 1.8 | 3.4 |
Vdss (l/kg) | 1.8 | 0.4 | 0.8 |
t1/2 (h) | 2.4 | 2.6 | 2.7 |
Total CLrenal (ml/min per kg)b | 3.0 | 0.6 | 0.7 |
↵a Observed pharmacokinetics in humans was as follows: CLp = 1.8–2.1 ml/min per kilogram and Vdss = 0.65–0.78 l/kg (20–200 mg p.o. doses) obtained from the respective CL/F and Vz/F values normalized for F values corresponding to the percentage of dose eliminated in unchanged form in urine in a 24-hour period at the respective p.o. doses. Human t1/2 was estimated to be 3.9–4.2 hours (20–200 mg p.o. doses) and was calculated using the equation 0.693 × Vdss/CLp.
↵b Observed total CLrenal in humans was1.8–2.1 ml/min per kilogram (20–200 mg p.o. doses).