Major metabolizing enzymes of test compounds and known metabolism differences across species
| Test Compounds | Major Metabolizing Enzyme | Species Difference |
|---|---|---|
| Sunitinib (1) | CYP3A | n/a |
| Trovafloxacin (2) | UGT1A1 | n/a |
| Carbazeran (3) | Aldehyde oxidase | Dog |
| Zoniporide (4) | Aldehyde oxidase | Dog |
| Tolbutamide (5) | CYP2C9 | Dog |
| Procainamide (6) | N-Acetyltransferase | Dog |
| Trifluoperazine (7) | UGT1A4 | Rat |