TABLE 1

Major metabolizing enzymes of test compounds and known metabolism differences across species

Test CompoundsMajor Metabolizing EnzymeSpecies Difference
Sunitinib (1)CYP3An/a
Trovafloxacin (2)UGT1A1n/a
Carbazeran (3)Aldehyde oxidaseDog
Zoniporide (4)Aldehyde oxidaseDog
Tolbutamide (5)CYP2C9Dog
Procainamide (6)N-AcetyltransferaseDog
Trifluoperazine (7)UGT1A4Rat