Parameter (Unit) | Definition | Value |
---|---|---|
(mL) | Plasma volume | 0.962 |
(mL) | Kidney volume | 0.417 |
(mL) | Liver volume | 1.37 |
(mL)a | Intestine volume | 0.632 |
fQVI (mL) | Enterocyte volume | — |
(1-fQ)VI (mL) | Serosal volume | — |
(mL) | Brain volume | 0.412 |
or Vothers (mL) | Peripheral compartment volume | 18.5 |
(mL × min−1)b | Plasma flow to kidney | 0.733 |
(mL × min−1)b | Plasma flow to liver | 1.3 |
QHA (mL × min−1)b | Hepatic arterial plasma flow rate | 0.26 |
(mL × min−1)a,b | Plasma flow to intestine | 1.04 |
Qen fQQI (mL × min−1) | Plasma flow to enterocyte | — |
Qser(1-fQ)QI (mL × min−1) | Plasma flow to serosa | — |
(mL × min−1)b | Plasma flow to brain | 0.266 |
(mL × min−1)c | Plasma cardiac output | 8.04 |
Partition coefficient of liver (liver to plasma concentration ratio) | 0.15 | |
Partition coefficient of kidney (kidney to plasma concentration ratio) | 0.34 | |
Partition coefficient of brain (brain to plasma concentration ratio) | 0.05 | |
Partition coefficient of intestine, serosa, or enterocyte (intestine to plasma concentration ratio) | 0.4 | |
(pM) | Baseline plasma 1,25(OH)2D3 concentration | 217 |
d (pmol × kg−1) | Baseline renal tissue 1,25(OH)2D3 concentration | 73.5 |
d (pmol × kg−1) | Baseline liver tissue 1,25(OH)2D3 concentration | 30.3 |
d (pmol × kg−1) | Baseline brain tissue 1,25(OH)2D3 concentration | 10.8 |
d (pmol × kg−1) | Baseline intestinal tissue 1,25(OH)2D3 concentration | 86.6 |
↵a For TM, fQ = 1; for SFM, fQ was estimated from fitting; fQ VI = Ven and (1-fQ) VI = Vser; fQQI = Qen and (1-fQ) QI = Qser.
↵b Values of tissue plasma flow were calculated as % plasma cardiac output (QCO) (Brown et al., 1997).
↵c Plasma cardiac output (QCO) for mice was calculated using an allometric relationship: QCO,mice (mL × min−1) = 275 × (1-Hct) × (body weight of mice in kg)0.75, where Hct is hematocrit (Brown et al., 1997).
↵d CT,baseline was calculated according to CP,baseline and the apparent KT value (CT,baseline/CP,baseline) for kidney, liver, brain, and intestine 0.34, 0.14, 0.05, and 0.4 (Chow et al., 2013); see Appendix.