1st Dosea | 2nd Dosea | 3rd Dosea | 4th Dosea | Combined Dosesa | Fitted Valuesb PBPK(TM)-PD | Fitted Valuesb PBPK(SFM)-PD | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Imax | IC50 | Imax | IC50 | Imax | IC50 | Imax | IC50 | Imax | IC50 | IC50 | IC50 | |
1 | 184 | 0.8 | 230 | 0.16 | 350 | 0.75 | 260 | 1 | 160 | 77.3 (7.03) | 66.8 (10.5) | |
Emax | EC50 | Emax | EC50 | Emax | EC50 | Emax | EC50 | Emax | EC50 | EC50 | EC50 | |
72 | 170 | 72 | 200 | 68 | 250 | 66 | 130 | 65 | 260 | 113 (1.75) | 248 (1.87) | |
500 | 727 | 650 | 1700 | 680 | 2600 | 630 | 2850 | 675 | 2300 | 2640 (0.703) | 2270 (2.89) | |
34 | 2250 | 47.7 | 3040 | — | — | 450 | 2530 | 170 | 2270 | 2600 (0.319) | 2900 (0.146) | |
49 | 250 | 49 | 235 | 36 | 119 | 43 | 74 | 49 | 106 | 235 (1.15) | 125 (8.35) |