Dose | AUC0–∞ | Cmax | Tmax | t1/2 | CL/F | Vz/F |
---|---|---|---|---|---|---|
mg | ng⋅h/ml | ng/ml | h | h | ml/min | liters |
20 | 1792 ± 363 | 402 ± 131 | 0.75 (0.5, 1.1) | 4.3 ± 0.7 | 186 ± 44 | 68.9 ± 10.8 |
50 | 4294 ± 664 | 920 ± 232 | 0.5 (0.5, 1.0) | 4.4 ± 0.6 | 194 ± 34 | 73.6 ± 11.5 |
125 | 10,730 ± 1950 | 2659 ± 631 | 0.5 (0.5, 1.0) | 4.4 ± 0.6 | 194 ± 40 | 73.7 ± 7.5 |
200 | 16,950 ± 2880 | 3799 ± 1156 | 0.5 (0.5, 2.0) | 4.3 ± 0.4 | 197 ± 32 | 72.6 ± 7.2 |