Pharmacokinetic parameters of CG and its metabolites in rat plasma after intravenous (0.5 mg/kg), intraperitoneal (10 mg/kg), and oral (0 mg/kg) administration of CG (n = 6)
| Cmax | Tmax | t1/2 | AUC0-t | AUC0-∞ | ||
|---|---|---|---|---|---|---|
| ng/ml | min | min | min·μg/ml | min·μg/ml | ||
| CG | i.v. | 446.1 ± 84.6 | —— | 22.99 ± 8.48 | 5.36 ± 1.02 | 5.39 ± 1.02 |
| p.o. | 7.46 ± 3.76 | 16.67 ± 6.83 | 91.16 ± 27.6 | 0.32 ± 0.11 | 0.33 ± 0.16 | |
| i.p. | 965.24 ± 133.53 | 15 ± 3.54 | 77.5 ± 17.91 | 71.98 ± 22.43 | 72.64 ± 22.08 | |
| CG glucuronide | i.v. | 5.41 ± 1.22 | 34.17 ± 18.28 | 57.29 ± 19.62 | 0.60 ± 0.31 | 0.77 ± 0.32 |
| p.o. | 51.29 ± 15.7 | 60 ± 23.24 | 61.68 ± 14.4 | 6.38 ± 3.31 | 6.40 ± 3.33 | |
| i.p. | 322.24 ± 125.53 | 66 ± 25.1 | 398.70 ± 291.04 | 100.88 ± 38.56 | 145.35 ± 67.10 | |
| Calycosin-3′-glucuronide | i.v. | 10.11 ± 3.17 | 19.17 ± 5.35 | 246.35 ± 204.6 | 2.04 ± 1.43 | 3.29 ± 3.02 |
| p.o. | 1189.66 ± 346.95 | 57.5 ± 25.8 | 171.49 ± 72.3 | 94.47 ± 20.76 | 111.16 ± 34.18 | |
| i.p. | 221.62 ± 86.60 | 66 ± 25.1 | 394.49 ± 289.11 | 69.11 ± 26.60 | 99.11 ± 45.90 |