MicroRNAs are shown to regulate the expression of xenobiotic receptors or transcription factors
| Nuclear receptor | miRNA | Experimental Methods | References |
|---|---|---|---|
| AHR | miR-124 | Reporter assay, mRNA and protein expression, association study | Huang et al., 2011 |
| NR1I1/ | miR-27b | Reporter assay, mRNA and protein expression | Pan et al., 2009a |
| miR-125b | Reporter assay, mRNA and protein expression | Mohri et al., 2009 | |
| miR-346 | Reporter assay, protein expression | Chen et al., 2014b | |
| NR1I2/PXR | miR-148a | Reporter assay, mRNA and protein expression | Takagi et al., 2008 |
| NR1I3/CAR | miR-137 | Association, reporter assay, mRNA/protein expression, function | Takwi et al., 2014) |
| NR1C1/PPARα | miR-10b | Reporter assay, mRNA and protein expression | Zheng et al., 2010 |
| miR-506 | Reporter assay, mRNA and protein expression, and function | Tong et al., 2011 | |
| miR-21 | Reporter assay, mRNA and protein expression, and function | Zhou et al., 2011 | |
| miR-21 & -27b | Reporter assay, mRNA/protein expression, function, association | Kida et al., 2011 | |
| miR-141 | Reporter assay, mRNA and protein expression | Hu et al., 2012 | |
| NR1H3/LXRα | miR-613 | Reporter assay, mRNA/protein expression, function | Ou et al., 2011 |
| miR-1/-206 | Reporter assay, mRNA/protein expression, function | Zhong et al., 2013; Vinod et al., 2014 | |
| NR2A1/HNF4α | miR-21 | Luciferase reporter assay | Wirsing et al., 2011 |
| miR-24 | Reporter assay, mRNA/protein expression, function | Takagi et al., 2010 | |
| miR-34/-449 | Reporter assay, mRNA/protein expression, function | Takagi et al., 2010; Wirsing et al., 2011; Ramamoorthy et al., 2012; Wang and Burke, 2013 | |
| NR2B1/RXRα | miR-27a/b | Reporter assay, mRNA & protein expression | Ji et al., 2009 |
| miR-128-2 | Reporter assay, mRNA and protein expression | Adlakha et al., 2013 | |
| miR-34a | Reporter assay, mRNA and protein expression, and association | Oda et al., 2014 | |
| NR3A1/ERα | miR-221/-222 | Reporter assay, mRNA/protein expression, association and function | Zhao et al., 2008; Guttilla et al., 2012; Wei et al., 2014a |
| Let-7 | Reporter assay, mRNA/protein expression, and function study | Zhao et al., 2011 | |
| miR-18a | Reporter assay, protein expression, association and function study | Liu et al., 2009 | |
| miR-18a/b, -19b, -20b, -193b, -206 | Reporter assay, protein expression | Castellano et al., 2009; Leivonen et al., 2009b | |
| miR-145 | Reporter assay, mRNA and protein expression, and function study | Spizzo et al., 2010 | |
| miR-22 | Reporter assay, protein expression, and function study | Pandey and Picard, 2009; Xiong et al., 2010 | |
| miR-206 | Reporter assay, protein expression, and function study | Adams et al., 2007; Kondo et al., 2008 | |
| miR-27a | via zinc finger and BTB domain containing 10 (ZBTB10) | Li et al., 2010a | |
| miR-219-5p | Reporter assay, mRNA/protein expression, association and function | Huang et al., 2015 | |
| miR-135b | Reporter assay, mRNA and protein expression | Aakula et al., 2015 | |
| NFE2L2/Nrf2 | miR-144 | Reporter assay, mRNA and protein expression, and function study | Sangokoya et al., 2010 |
| miR-28 | Reporter assay, mRNA and protein expression | Yang et al., 2011 | |
| miR-200a | (Activation) via Kelch-like ECH-associated protein 1 (Keap1) | Eades et al., 2011; Yang et al., 2014 | |
| miR-153, -27a, -142-5p, -144 | Reporter assay, mRNA and protein expression, and function study | Narasimhan et al., 2012, 2014 | |
| miR-93 | Protein expression, and function study | Singh et al., 2013 | |
| miR-507, -634, -450, -129-5p | Reporter assay, mRNA and protein expression, and function study | Yamamoto et al., 2014 | |
| miR-34a | mRNA and protein expression | Huang et al., 2014 | |
| miR-340 | Reporter assay, mRNA and protein expression, and function study | Shi et al., 2014a | |
| miR-141 | via Kelch-like ECH-associated protein 1 (Keap1) | Shi et al., 2015 |