TABLE 1

Pharmacokinetic parameters of DF and DF-AG following a single oral 50-mg dose of DF

Data are reported as the mean ± S.D. of six different subjects.

ParameterDFDF-AGDF-AG/DF ratio
Cmax (nM)3076 ± 5311846 ± 5280.62 ± 0.21
Tmax (hours)1.25 ± 0.581.25 ± 0.58
AUClast(nM*h)4046 ± 6353466 ± 11680.83 ± 0.20
AUCtot (nM*h)4126 ± 6273593 ± 11850.84 ± 0.21
  • AUClast, AUC up to the last quantifiable time point.