WT Lean | WT DIO | NFR Lean | NFR DIO | |
---|---|---|---|---|
Day 1 AUC0–∞ (μM*h) | 8.3 ± 2.1 | 35 ± 4.0 | 13 ± 1.3 | 51 ± 11 |
AUC0–24h (μM*h) | 7.8 ± 1.7 | 29 ± 3.8 | 9.8 ± 0.8 | 25 ± 6.2 |
Cmax (μM) | 2.7 ± 0.8 | 5.2 ± 1.5 | 2.8 ± 0.8 | 5.0 ± 1.3 |
T 1/2 (h) | 14 ± 4.6 | 17 ± 3.3 | 23 ± 6.1 | 60 ± 25 |
Day 42 | ||||
AUC0–∞ (μM*h) | 14 ± 1.2 | 93 ± 28 | 48 ± 26 | 118 ± 33 |
AUC0–24h (μM*h) | 9.2 ± 0.8 | 44 ± 4.5 | 13 ± 1.3 | 45 ± 8.5 |
Cmax (μM) | 2.7 ± 0.4 | 6.1 ± 1.3 | 3.4 ± 0.9 | 6.8 ± 1.3 |
T 1/2 (h) | 74 ± 31 | 63 ± 36 | 152 ± 127a | 66 ± 34a |
↵a Some uncertainty in t½ calculation, due to secondary peaks in blood concentration time profile.