TABLE 1

Parameter estimates derived from application of the mechanistic model to metformin uptake in HEK-EV and HEK-OCT1 cells

ParameterER ∆φ = −80 mVER ∆φ = 0 mV
EstimatesStandard Error (%)EstimatesStandard Error (%)
Pn (cm/sec)0.247420.24986
Pn/Pi39,9321724,24224
α12.15238.2414
β9.18265.5618
Km (µM)68.042983.6118