Summary of intrinsic clearance and fm of validation compounds
| Compounds | Intrinsic Clearance | fm (Hepatocyte Relay Reaction Phenotyping) | fm (Literature Data) |
|---|---|---|---|
| ml/mg/kg | |||
| Erythromycin | 9.0 | CYP3A 0.84 | Mostly CYP3A (Karlsson et al., 2013) |
| Tizanidine | 8.8 | CYP1A2 0.83 | CYP1A2 0.85 (Granfors et al., 2004) |
| Timolol | 14 | CYP2D6 0.74 | CYP2D6 (major), CYP2C19 (minor) (Volotinen et al., 2007; Volotinen et al., 2010) |
| Tolbutamide | 7.4 | CYP2C9 0.90 | CYP2C9 0.8 to 1 (Miller et al., 1990; Srivastava et al., 1991; Veronese et al., 1991; Hall et al., 1994; Komatsu et al., 2000; Wester et al., 2000) |
| Diazepam | 15 | CYP3A 0.56 CYP2C19 0.42 | CYP3A 0.50 CYP2C19 0.50 (Andersson et al., 1994; Zvyaga et al., 2012), |