Ki (μM)a values for competitive inhibition of P450 isoforms by deleobuvir, CD 6168, and deleobuvir-AG
| P450 Isoform | Deleobuvir | CD 6168 | Deleobuvir-AG | |||
|---|---|---|---|---|---|---|
| Total | Freeb | Total | Free | Total | Free | |
| CYP1A2 | NA | NA | NA | NA | 12.5 | 6.13 |
| CYP2B6 | 17.5 | 11.3 | NA | NA | 20.4 | 9.99 |
| CYP2C8 | 0.13 | 0.087 | 0.27 | 0.21 | 0.022 | 0.0108 |
| CYP2C9 | 4.7 | 3.0 | 18 | 13.5 | 14.4 | 7.06 |
| CYP2C19 | NA | NA | NA | NA | 26 | 12.7 |
| CYP2D6 | NA | NA | NA | NA | 50 | 24.5 |
| CYP3A4 | 7.4 | 4.4 | 23 | 17 | 12 | 5.88 |