TABLE 3
Kinetic parameters of prasugrel hydrolysis by DIMs and dog AADAC
Enzyme source
K
m
V
max
CL
int
μM
nmol/min/mg protein
ml/min/mg protein
DIM
5.3 ± 0.6
29.8 ± 2.0
5.6 ± 0.3
AADAC
1.5 ± 0.1
67.4 ± 6.5
45.9 ± 3.1