Kinetic parameters (mean ± standard deviation) of the transporter-mediated uptake of pitavastatin determined using either HEK293 cells (SLC transporters) or membrane vesicles (ABC transporters)
| Transporter | Km | Vmax |
|---|---|---|
| µM | pmol/min/mg protein | |
| NTCP (SLC10A1) | 38.2 ± 12.1 | 3029 ± 283 |
| OATP1B1 (SLCO1B1) | 0.810 ± 0.241 | 68.5 ± 6.36 |
| OATP1B3 (SLCO1B3) | 2.60 ± 3.26 | 30.2 ± 12.6 |
| OATP2B1 (SLCO2B1) | 13.5 ± 3.41 | 483 ± 46.7 |
| BCRP (ABCG2) | 1.20 ± 0.594 | 95.3 ± 9.39 |
| MDR1 (ABCB1) | 83.7 ± 32.6 | 433 ± 41.1 |
| MRP3 (ABCC3) | 448 ± 273 | 2380 ± 463 |