TABLE 1

Comparison of the whole-cell conversions with CYP267A1 and CYP267B1 using different redox partners

Model SubstrateCYP267Conversion with
heterologous Adx4-108/FpraConversion with
autologous Fdx8/FdR_BProduct
%%
AmitriptylineB17.52610-Hydroxyamitriptylinea
Chlorpromazine (2)B11830Chlorpromazine sulfoxidea (2a)
Thioridazine (20)A1545Thioridazine-5-sulfoxidea (20a)

  • ↵a Taken from Litzenburger et al. (2015).