Kinetic parameters of prasugrel hydrolysis by recombinant esterases and human tissue microsomes
| Enzyme Source | Km | Vmax | CLint |
|---|---|---|---|
| μM | nmol/min/mg protein | ml/min/mg protein | |
| AADAC | 4.6 ± 0.2 | 228.4 ± 13.6 | 50.0 ± 1.2 |
| CES1 | 16.7 ± 1.9 | 76.5 ± 6.9 | 4.6 ± 0.1 |
| CES2 | 17.1 ± 1.8 | 111.7 ± 6.8 | 6.6 ± 0.3 |
| HIM | 5.3 ± 0.2 | 560.6 ± 20.7 | 106.4 ± 1.4 |
| HLM | 4.6 ± 0.5 | 382.0 ± 27.9 | 83.9 ± 3.1 |