Comparison of metabolic lability in pooled human liver microsomes between drugs and their fluorinated analogs
| Compound | CLint (μl/min per milligram of protein) | Stability Factor | |
|---|---|---|---|
| Parent Drug | Fluorinated Analog | ||
| Midazolam | 691 (38) | 507 (23) | 1.4 |
| Ramelteon | 63 (18) | 95 (10) | 0.66 |
| Celecoxib | 23 (5) | 34 (4) | 0.67 |
| Risperidone | 40 (1) | 27 (5) | 1.5 |
Values in parentheses are standard errors.