Comparison of plasma PK parameters for SV and SVA between a mouse ependymoma model (100 mg/kg SV, p.o.) and human patients (7.5 mg/kg SV, p.o.)
| Parameter | Mice (n = 15)a | Humans (n = 3) | ||
|---|---|---|---|---|
| SV | SVA | SV | SVA | |
| AUC0–12 (μg/l per hour) | 51.9 ± 39.5 | 362.8 ± 54.2 | 795.3 ± 753.4 | 349.3 ± 218.3 |
| Cmax (μg/l) | 28.6 ± 19.0 | 178.3 ± 36.3 | 376.7 ± 460.4 | 109 ± 131.0 |
| Tmax (h) | 0.23 ± 0.13 | 0.55 ± 0.14 | 1.3 ± 0.5 | 3.3 ± 2.5 |
↵a Parameters obtained by simulation. Data are presented as means ± S.D. Human data are from Ahmed et al. (2013).