TABLE 3

Biochemical changes in response to endotoxin administration

Values are presented as means ± S.E.M.

	Saline-Treated Rats	Endotoxin (LPS)–Treated Rats
Serum alanine transaminase activity (mU/ml)
Male WT	87 ± 74	2218 ± 498
Male HIV-Tg	433 ± 223	6236 ± 2656^*
Female WT	686 ± 445	3473 ± 1874
Female HIV-Tg	269 ± 144	6907 ± 1036**^,#
Serum total bile acid concentrations (μM)
Male WT	25 ± 3	49 ± 7
Male HIV-Tg	26 ± 4	118 ± 26**^,##
Female WT	14 ± 6	103 ± 50
Female HIV-Tg	9 ± 6	252 ± 37**^,##
Hepatic bile acid concentrations (μM)
Male WT	31 ± 3.3	40 ± 0.6^*
Male HIV-Tg	27 ± 3.2	40 ± 1.99***
Female WT	31 ± 8.8	37 ± 2.5
Female HIV-Tg	37 ± 4.4	34 ± 3.0

↵* P < 0.05; **P < 0.01; ***P < 0.001; ^#P < 0.05; ^##P < 0.01 (asterisks indicate values that are significantly different from saline controls, pound signs indicate values that are significantly different from endotoxin-treated WT).