Compound | Enzyme | CLint (μl/min per picomole P450) | ||
---|---|---|---|---|
Parent Drug | Fluorinated Analog | Stability Factor | ||
Midazolam | CYP3A4 | 23.4 (0.7) | 17.7 (0.7) | 1.3 |
Midazolam | CYP3A5 | 45.9 (1.0) | 15.3 (0.5) | 3.0 |
Ramelteon | CYP1A2 | 27.3 (6.4) | 28.8 (5.1) | 0.95 |
Celecoxib | CYP2C9 | 3.0 (0.4) | 0.78 (0.15) | 3.8 |
Risperidone | CYP2D6 | 5.6 (0.3) | 0.34 (0.37) | 16 |
Values in parentheses are standard errors.