SPR-derived CYP2C9 equilibrium dissociation constants
Average equilibrium dissociation constants (KD) ± S.E.M. are given for the binding of CYP2C9 with the indicated partner. Values were calculated by fitting the SPR sensorgrams with both Biacore Evaluation or Scrubber 2.0 software and assuming 1:1 stoichiometry. SPR runs were performed in triplicate on separate days.
| Partner | CYP2D6 | CYP2C9 | CYP3A4 | CPR |
|---|---|---|---|---|
| nM | ||||
| KD | 1.1 ± 0.5 | 2.6 ± 1.0 | 18.1 ± 3.0 | 7.3 ± 2.2 |