TABLE 2

Calculated rate constants for the disposition of brivaracetam and its metabolites, with and without rifampin

Rate Constant (1/h)^{^a}	Brivaracetam (Reference)	Brivaracetam Plus Rifampin (Test)	Ratio (Test/Reference)
k₁₀ (BRV urinary excretion)	0.013 (25.1)	0.022 (28.6)	1.82
k₂₀ (BRV-AC urinary excretion)	0.433 (19.1)	0.532 (23.3)	1.23
k₃₀ (BRV-OH urinary excretion)	0.204 (57.3)	0.177 (19.3)	0.95
k₄₀ (BRV-OHAC urinary excretion)	0.851 (12.6)	0.919 (19.4)	1.08
k₁₂ (BRV → BRV-AC)	0.049 (13.6)	0.049 (13.6)	1.00^{^b}
k₁₃ (BRV → BRV-OH)	0.025 (44.5)	0.089 (34.0)	3.67
k₂₄ (BRV-AC → BRV-OHAC)	0.192 (26.6)	0.210 (51.1)	1.12
k₃₄ (BRV-OH → BRV-OHAC)	0.081 (119.7)	0.081 (119.7)	1.00^{^b}