Mouse | Rat | BDC Dog | Monkey | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
1 h | 4 h | 1 h | 2 h | 4 h | 1.5 h | 4 h | 8 h | 1 h | 4 h | 8 h | |
1 | 89.8 | 74.6 | 84.6 | 85.2 | 88.2 | 87.5 | 92.4 | 93.9 | 78.2 | 74.2 | 85.6 |
3 | 1.6 | 4.0 | 2.9 | 2.8 | 2.6 | ms | ms | ms | 21.8 | 17.8 | 14.4 |
4 | 3.2 | 2.1 | 2.0 | 3.0 | 1.9 | ms | 2.3 | 2.0 | — | — | — |
5 | 1.5a | 3.0a | — | — | — | ms | 1.2a | 0.6a | — | — | — |
26 | 4.5 | 4.0 | 3.5 | ms | — | — | — | ||||
7 | 2.8 | 6.7 | — | — | — | — | — | — | — | — | — |
8 | — | — | 1.5 | 2.0 | 1.5 | — | — | — | — | — | — |
9 | ms | 1.5 | 0.3 | 0.7 | 0.7 | 2.9 | ms | ms | — | — | — |
10 | ms | 2.4 | — | — | — | — | — | — | — | — | — |
12 | — | — | — | — | — | — | — | — | ms | 2.1 | ms |
Sum | 98.9 | 94.3 | 95.8 | 97.7 | 98.4 | 90.4 | 95.9 | 96.5 | 100.0 | 94.1 | 100.0 |
—, not detected; ms, detected by mass spectrometry only.
↵a Compounds 5 and 26 coeluted during HPLC. Entries represent the sum of radioactivity attributed to these two metabolites.