In vitro induction parameters (Indmax and IndC50) for rifampicin, carbamazepine, phenobarbital, and phenytoin generated using mRNA and activity data
Data are shown as the mean and standard deviation from four human hepatocyte donors. Where Indmax is the maximum fold induction (equal to Emax +1) and IndC50 is the concentration that gives half maximal fold induction (analogous to EC50).
| Activity | mRNA | ||||
|---|---|---|---|---|---|
| Indmax | IndC50 | Indmax | IndC50 | ||
| fold | µM | fold | µM | ||
| Rifampicin | Mean | 22.7 | 0.30 | 29.9 | 0.71 |
| S.D. | 7.8 | 0.10 | 7.0 | 0.35 | |
| Carbamazepine | Mean | 16.6 | 59.1 | 21.9 | 58.7 |
| S.D. | 6.1 | 37.3 | 12.4 | 18.0 | |
| Phenobarbital | Mean | 21.1 | 473 | 44.2 | 743 |
| S.D. | 11.5 | 245 | 25.9 | 334 | |
| Phenytoin | Mean | 13.6 | 51.3 | 24.5 | 123 |
| S.D. | 3.7 | 29.4 | 7.6 | 120 | |
| Efavirenz | Mean | 13.5 | 4.9 | 18.1 | 8.4 |
| S.D. | 4.2 | 1.7 | 5.4 | 5.1 | |
| Nifedipine | Mean | 15.6 | 4.0 | 30.0 | 13.0 |
| S.D. | 11.3 | 1.9 | 22.0 | 9.5 | |