Relative contributions of brivaracetam disposition pathways and hydroxy acid formation routes
| Pathway | Percentage (CV%) |
|---|---|
| Clearance of brivaracetam | |
| BRV → BRV-AC (hydrolysis) | 56.4 (15.3) |
| BRV → BRV-OH (hydroxylation) | 28.2 (31.0) |
| Other pathways | 15.5 (26.4) |
| Formation of BRV-OHAC | |
| BRV-AC → BRV-OHAC (hydroxylation) | 69.9 (18.8) |
| BRV-OH → BRV-OHAC (hydrolysis) | 30.1 (43.8) |
CV%, coefficient of variation (%).