TABLE 3

Final population model estimates

ParameterMean Parameter EstimateS.E.
Ka (1/h; wild-type rs4148157)0.610.11
θ11.060.25
Ka (1/h; variant rs4148157)1.760.49
V/F (l)40.27.0
θ20.780.48
CL/F (l/h)40.02.9
θ31.250.39
ω -BSV
 Ka0.5170.12
 V/F0.3380.17
 CL/F0.4650.11
σ -RUV
 Additive (ng/ml)0.5920.44
  • BSV, between-subject variability; RUV, residual unexplained variability; θ1, estimated coefficient of the effect of ABCG2 rs4148157 G>A heterozygotes and homozygotes on the absorption rate constant; θ2, estimated exponent of the effect of the BSA on apparent volume of distribution; θ3, estimated exponent of the effect of the BSA on apparent clearance.