CYP2B6 diplotype frequencies
CYP2B6 haplotypes were determined by PHASE (version 2.1) and haplotypes were assigned according to CYP2B6 nomenclature and are summarized in Table 3. For 11 of the 201 liver tissue samples, haplotype combinations could not unequivocally be determined, i.e., there is a probability that a subject has an alternate diplotype. The less likely diplotype is provided as the alternate diplotype; probabilities are shown in parentheses.
| CYP2B6 Diplotype | Alternate Diplotype (Probability) | Number of Subjects (n = 201) | Genotype Frequency (n = 201) |
|---|---|---|---|
| *1/*1 | 58 | 28.86 | |
| *1/*4 | 5 | 2.49 | |
| *1/*5 | 24 | 11.94 | |
| *1/*6 | 74 | 36.82 | |
| *1/*18 | 4 | 1.99 | |
| *1/*22 | 2 | 1.00 | |
| *4/*6 | 1 | 0.50 | |
| *5/*5 | 2 | 1.00 | |
| *5/*6 | 6 | 2.99 | |
| *6/*6 | 12 | 5.97 | |
| *18/*18 | 2 | 1.00 | |
| *4/*5 | *1/*16 (0.01) | 1 | 0.50 |
| *6/*N1 | *9/*N3 (0.48) | 1 | 0.50 |
| *3/*22 | *1/*N2 (0.5) | 1 | 0.50 |
| *18/*22 | *1/*N4 (0.14) | 2 | 1.00 |
| *6/*18 | *1/*N5 (0.01) | 5 | 2.49 |
| *4/*18 | *1/*N6 (0.02) | 1 | 0.50 |