Hepatic protein expressions
| Fetuses N = 10 | Infants N = 12 | Adults N = 3 | Age Group versus Expression (P value) | ||
|---|---|---|---|---|---|
| Profile I: stable | OATP1B1 | 17.6 (5.4–35.6) | 22.8 (9.5–47.9) | 34.6 (21.5–57.5) | 0.126 |
| OATP2B1 | 42.2 (29.3–59.3) | 38.5 (27.2–46.3) | 44.9 (30.1–48.9) | 0.580 | |
| ABCB1 | 79.2 (23.2–117.7) | 107.9 (60.6–150.6) | 96.9 (93.5–103.4) | 0.065 | |
| ABCC2 | 8.8 (5.5–9.9) | 12.6 (5.3–43.9) | 19.8 (15.5–22.2) | 0.010 | |
| Profile II: low to high | ABCC3 | 5.4 (1.6–9.9) | 21.9 (3.6–32.8) | 23.1 (15.9–23.7) | 0.012 |
| BSEP | 18.4 (11.4–33.7) | 35.9 (10.6–49.8) | 47.7 (40.3–67.0) | 0.005* | |
| Profile III: high to low | ABCG2 | 4.0 (2.2–7.0) | 2.7 (1.5–4.2) | 1.7 (0.8–2.2) | 0.006* |
| GLUT1 | 434.2 (49.1–1413.3) | 108.7 (39.0–255.4) | 5.2 (5.1–7.7) | <0.000* | |
| OCTN2 | 6.3 (4.1–8.9) | 4.4 (1.9–6.6) | 3.0 (2.2–4.8) | 0.014 | |
| Profile IV: nonlinear | MCT1 | 12.9 (10.0–20.0) | 20.3 (10.8–39.0) | 9.8 (8.9–12.4) | 0.002* |
Data are expressed as median (range) protein expressions in pmol/g tissue, P value. *Significant after Bonferroni correction (0.05/10 = 0.005).