TABLE 1

Tissue sample donor demographics

To ensure good age representation and adequate power, target sample sizes for birth to 30 days, greater than 30 days to 1 year, greater than 1–5 years, greater than 5–10 years, and greater than 10–18 years age brackets were developed based on data from the existing literature on drug and toxicant metabolizing enzyme ontogeny. Samples sizes were sufficient to provide at least 80% power to detect a 1 S.D. change in enzyme specific content between age brackets assuming α = 0.05.

VariableMedianRange
Age at death (mo)3.70–212
Postmortem interval (h)171–41
No.% of Total
Hepatic tissue samples165100
SexMale10463
Female5835
Unknown32
Ethnicity/raceNorthern European white7948
African American6238
Hispanic1610
Asian21
Native American1<1
Unknown53