TABLE 1

Adalimumab concentrations and clinical remission (at week 26 for pediatrics and week 24 for adults)

Population	C_trough at Week 26^a (Mean ± S.D.)	Clinical Remission at Week 26
	µg/ml
Pediatrics
<40 kg (N = 39)
10 mg EOW (N = 19)	2.0 ± 1.4	5/19 (26.3%)
20 mg EOW (N = 20)	7.6 ± 3.6	8/20 (40.0%)
≥40 kg (N = 94)
20 mg EOW (N = 47)	3.7 ± 2.71	20/47 (42.6%)
40 mg EOW (N = 47)	10.7 ± 4.6	23/47 (48.9%)
Adults^b
N = 94
40 mg EOW	6.8 ± 4.3	54/94 (57.4%)
N = 260
40 mg EOW	NA	87/260 (33.5%)

↵^a Data from 42 subjects are missing.
↵^b Data in adults were taken from the submission for adult CD, and the clinical remission was based on the Crohn’s Disease Activity Index (pediatrics clinical remission was based the PCDAI).