TABLE 2

CYP2B6 mRNA expression, protein content, and bupropion hydroxylase activity

	Prenatal, 78–147 Days (PCA)	Pediatric			Adult, 18–79 Years
	Prenatal, 78–147 Days (PCA)	0 to <1 Years	1 to <12 Years	12 to <18 Years	Adult, 18–79 Years
mRNA expression (molecules/15 ng)
Arithmetic mean	0.72	599	4503	673	3364
Geometric mean	0.58	274	961	283	700
mRNA expression range	0.22–3.4	0.70–1479	2.29–28,744	16.8–2751	4.6–17,170
mRNA expression fold variation	16	2113	12,551	164	3700
Sample number	24	12	44	23	26
Protein expression (pmol/mg protein)
Arithmetic mean	2.35	1.23	5.11	1.35	7.65
Geometric mean	2.19	0.86	2.18	1.02	2.93
Protein expression range	0.73–3.55	0.24–9.04	0.15–47.39	0.2–9.59	0.30–32.00
Protein expression fold variation	5	38	316	48	107
Sample number	24	28	64	49	36
Activity (pmol/mg protein/min)
Arithmetic mean	0	55	347	88	523
Geometric mean	0	24	125	43	143
Activity range^{^a}	N/A	5.74–553	6.34–3714	5.73–508	5.95–2366
Activity fold variation	N/A	96	585	88.7	398
Sample number	24	19	58	37	32

N/A, not applicable; PCA, post-conceptual age.
↵^a CYP2B6 activity range covers lowest to highest measurable activities for each age group.