Prenatal, 78–147 Days (PCA) | Pediatric | Adult, 18–79 Years | |||
---|---|---|---|---|---|
0 to <1 Years | 1 to <12 Years | 12 to <18 Years | |||
mRNA expression (molecules/15 ng) | |||||
Arithmetic mean | 0.72 | 599 | 4503 | 673 | 3364 |
Geometric mean | 0.58 | 274 | 961 | 283 | 700 |
mRNA expression range | 0.22–3.4 | 0.70–1479 | 2.29–28,744 | 16.8–2751 | 4.6–17,170 |
mRNA expression fold variation | 16 | 2113 | 12,551 | 164 | 3700 |
Sample number | 24 | 12 | 44 | 23 | 26 |
Protein expression (pmol/mg protein) | |||||
Arithmetic mean | 2.35 | 1.23 | 5.11 | 1.35 | 7.65 |
Geometric mean | 2.19 | 0.86 | 2.18 | 1.02 | 2.93 |
Protein expression range | 0.73–3.55 | 0.24–9.04 | 0.15–47.39 | 0.2–9.59 | 0.30–32.00 |
Protein expression fold variation | 5 | 38 | 316 | 48 | 107 |
Sample number | 24 | 28 | 64 | 49 | 36 |
Activity (pmol/mg protein/min) | |||||
Arithmetic mean | 0 | 55 | 347 | 88 | 523 |
Geometric mean | 0 | 24 | 125 | 43 | 143 |
Activity rangea | N/A | 5.74–553 | 6.34–3714 | 5.73–508 | 5.95–2366 |
Activity fold variation | N/A | 96 | 585 | 88.7 | 398 |
Sample number | 24 | 19 | 58 | 37 | 32 |
N/A, not applicable; PCA, post-conceptual age.
↵a CYP2B6 activity range covers lowest to highest measurable activities for each age group.