Fraction of each compound assigned on the basis of literature evidence to be eliminated by direct biliary, renal, and hepatic metabolic elimination in adult healthy volunteers and performance of the model in these subjects
| Drug | Mean Percentage Eliminated | Clearance (Mean ± S.D.) | |||
|---|---|---|---|---|---|
| Renal | Biliary | Hepatic Metabolism | Obs | Pred | |
| l/h | l/h | ||||
| Azithromycin | 22 | 78 | — | 46.5 ± 6.4 | 45.0 ± 8.9 |
| Ceftriaxone | 60 | 40 | — | 1.30 ± 0.9 | 1.32 ± 0.31 |
| Digoxin | 65 | 30 | 5 | 13.5 ± 5.9 | 12.5 ± 2.35 |
| Buprenorphine | 1 | 17 | 50 CYP3A4 | 61.4 ± 18.8 | 55.5 ± 9.93 |
| 32 UGT1A1 | |||||