TABLE 6

Comparison of the goodness of fit among the three models

Statistic Parameters	Two-Compartmental Model	TM-PBPK	SFM-PBPK
Weighted residual sum of squares	445	419	394
F value
Versus two-compartment model	—^{^}	4.31^{^a}	7.83^{^a}
Versus TM-PBPK model	—	—	23.0^{^a}

↵^{^} not applicable;
↵^a Calculated F score > critical F value of 4.0, suggesting the order of goodness of fit: two-compartment model < TM-PBPK < SFM-PBPK.